News for Healthier Living

Engineering Yeast to Make Rare Anticancer Saponins: Reconstructing the Complete Biosynthesis of Polyphyllin II

A research team has uncovered and reconstructed the complete biosynthetic pathway of polyphyllin II--a potent anticancer steroidal saponin--by identifying and engineering a key glycosyltransferase and transferring the optimized pathway into yeast.

January 18, 2026


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